A theory suggests that the painting of Mona Lisa is not of a woman but instead a self portrait of da Vinci wearing woman’s clothes.

The artist Susan Dorothea White has interpreted the masculine proportions of Mona Lisa's cranial architecture in her anatomical artworks Anatomy of a Smile: Mona's Bones (2002) and Mona Masticating (2006).Lillian Schwartz of Bell Labs suggests that the Mona Lisa is actually a self-portrait. She supports this theory with the results of a digital analysis of the facial features of the woman in the painting and those of the famous possible self-portrait drawing by Leonardo. When the drawing is reversed and then merged with an image of the Mona Lisa using a computer, the features of the faces align perfectly.